Mysterio has a wide variety of tattoos, including dedications to his family.
Mysterio and his wife Angie have three children. He has tattoos of his two oldest children's names on his right and left biceps. He also has tattoos dedicated to his wife, Angie.
On March 19, 2007, Sports Illustrated posted on its website an article in its continuing series investigating a steroid and HGH ring used by a number of professional athletes in several sports. That article mentioned several current and former WWE wrestlers, including Mysterio who was alleged to have obtained nandrolone and stanozolol. WWE subsequently stated that the allegations preceded the Talent Wellness program WWE launched in February 2006. On August 27, 2009, WWE announced that Gutiérrez would receive a 30 day suspension due to a violation of the wellness program. Days later Gutiérrez defended himself in a newspaper interview by explaining the drugs as being on a prescription for his knee and arm. While the Wellness Policy allows for prescribed drugs, Mysterio further contested he had been on a family holiday and subsequently in Europe promoting SummerSlam, giving him only a day to provide the prescription after being notified.
He is a devoted Roman Catholic, frequently crossing himself before every match and bearing numerous religious tattoos on his body, most notably a cross on his chest attached to rosaries as well as other crosses and allusions to God. Gutiérrez is friends with Noah "Wuv" Bernardo of P.O.D., who performed the original version of Booyaka along with Mysterio, and several other of Mysterio's themes in WCW.
